The course will introduce students to a selected set of laboratory techniques that are foundational to modern biological research.

This laboratory course is compulsory for physics students with the elective subject biophysics. The topic of the work is determined individually, and will be in the context with ongoing research projects. Possible topics are NMR investigations with proteins, NMR structure determination of proteins in solution, development of novel NMR experiments, studies of protein folding.

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The course gives insight into the methodology, areas of application and limitations of the two principal methods for the structure determination of biological macromolecules.

Insight into the methodology, areas of application and limitations of the two principal methods for the structure determination of biological macromolecules.

The course consists of a series of research seminars on Structural Biology and Biophysics, given by both scientists of the National Center of Competence in Research (NCCR) in Structural Biology and external speakers.

This course provides an in-depth discussion of two main methods to determine the 3D structures of macromolecules and complexes at high resolution: X-ray crystallography and cryo-electron microscopy. Both techniques result in electron density maps that are interpreted by atomic models.

The course provides an overview of experimental methods for studying function and structure of macromolecules at atomic resolution in solution. The two main methods used are Nuclear Magnetic Resonance (NMR) spectroscopy and Electron Paramagnetic Resonance (EPR) spectroscopy.

The course consists of a series of research seminars on Structural Biology, Biochemistry and Biophysics, given by both scientists of the National Center of Competence in Research (NCCR) in Structural Biology and external speakers. Information on the individual seminars is provided on the following websites:http://www.structuralbiology.uzh.ch/educ002.asphttp://www.biol.ethz.ch/dbiol-cal/index

In this block course, students actively participate in ongoing research projects in the research groups of Profs. Allain, Wüthrich and Dr. Gossert. The students will be tutored in their experimental work by experienced postdoc students. In addition, the course includes specific lectures that provide the theoretical background for the experimental work, as well as exercises and literature work.

The course provides an overview of experimental methods for the determination of high-resolution structures of macromolecules.